{"id":4417,"date":"2025-08-14T13:35:23","date_gmt":"2025-08-14T17:35:23","guid":{"rendered":"https:\/\/csem.ubmepsilon.com\/nexavar\/"},"modified":"2025-08-14T13:41:16","modified_gmt":"2025-08-14T17:41:16","slug":"nexavar","status":"publish","type":"page","link":"https:\/\/csem.ubmepsilon.com\/fr\/nexavar\/","title":{"rendered":"Nexavar"},"content":{"rendered":"<p>[et_pb_section fb_built=\u00a0\u00bb1&Prime; custom_padding_last_edited=\u00a0\u00bbon|tablet\u00a0\u00bb module_class=\u00a0\u00bbjoin-section\u00a0\u00bb _builder_version=\u00a0\u00bb4.27.4&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb custom_padding=\u00a0\u00bb0px|20px|50px|20px|false|false\u00a0\u00bb custom_padding_tablet=\u00a0\u00bb20px|20px|20px|20px|false|false\u00a0\u00bb custom_padding_phone=\u00a0\u00bb20px|20px|20px|20px|false|false\u00a0\u00bb custom_css_main_element=\u00a0\u00bboverflow-x:hidden;\u00a0\u00bb da_disable_devices=\u00a0\u00bboff|off|off\u00a0\u00bb locked=\u00a0\u00bboff\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb da_is_popup=\u00a0\u00bboff\u00a0\u00bb da_exit_intent=\u00a0\u00bboff\u00a0\u00bb da_has_close=\u00a0\u00bbon\u00a0\u00bb da_alt_close=\u00a0\u00bboff\u00a0\u00bb da_dark_close=\u00a0\u00bboff\u00a0\u00bb da_not_modal=\u00a0\u00bbon\u00a0\u00bb da_is_singular=\u00a0\u00bboff\u00a0\u00bb da_with_loader=\u00a0\u00bboff\u00a0\u00bb da_has_shadow=\u00a0\u00bbon\u00a0\u00bb][et_pb_row use_custom_gutter=\u00a0\u00bbon\u00a0\u00bb gutter_width=\u00a0\u00bb1&Prime; 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custom_padding_last_edited=\u00a0\u00bbon|tablet\u00a0\u00bb module_class=\u00a0\u00bbjoin-section\u00a0\u00bb _builder_version=\u00a0\u00bb4.27.4&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb custom_padding=\u00a0\u00bb0px|20px|50px|20px|false|false\u00a0\u00bb custom_padding_tablet=\u00a0\u00bb20px|20px|20px|20px|false|false\u00a0\u00bb custom_padding_phone=\u00a0\u00bb20px|20px|20px|20px|false|false\u00a0\u00bb custom_css_main_element=\u00a0\u00bboverflow-x:hidden;\u00a0\u00bb da_disable_devices=\u00a0\u00bboff|off|off\u00a0\u00bb border_width_top=\u00a0\u00bb1px\u00a0\u00bb border_color_top=\u00a0\u00bb#ebebeb\u00a0\u00bb locked=\u00a0\u00bboff\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb da_is_popup=\u00a0\u00bboff\u00a0\u00bb da_exit_intent=\u00a0\u00bboff\u00a0\u00bb da_has_close=\u00a0\u00bbon\u00a0\u00bb da_alt_close=\u00a0\u00bboff\u00a0\u00bb da_dark_close=\u00a0\u00bboff\u00a0\u00bb da_not_modal=\u00a0\u00bbon\u00a0\u00bb da_is_singular=\u00a0\u00bboff\u00a0\u00bb da_with_loader=\u00a0\u00bboff\u00a0\u00bb da_has_shadow=\u00a0\u00bbon\u00a0\u00bb][et_pb_row use_custom_gutter=\u00a0\u00bbon\u00a0\u00bb gutter_width=\u00a0\u00bb1&Prime; custom_padding_last_edited=\u00a0\u00bbon|tablet\u00a0\u00bb _builder_version=\u00a0\u00bb4.27.4&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb width=\u00a0\u00bb100%\u00a0\u00bb custom_padding=\u00a0\u00bb||0px||false|false\u00a0\u00bb custom_padding_tablet=\u00a0\u00bb0px||||false|false\u00a0\u00bb custom_padding_phone=\u00a0\u00bb0px||||false|false\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_column type=\u00a0\u00bb4_4&Prime; _builder_version=\u00a0\u00bb4.27.4&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=\u00a0\u00bb4.27.4&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb width=\u00a0\u00bb100%\u00a0\u00bb max_width=\u00a0\u00bb1280px\u00a0\u00bb custom_padding=\u00a0\u00bb0px||0px||false|false\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_column type=\u00a0\u00bb4_4&Prime; _builder_version=\u00a0\u00bb4.27.4&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb][et_pb_text _builder_version=\u00a0\u00bb4.27.4&Prime; _module_preset=\u00a0\u00bbdefault\u00a0\u00bb hover_enabled=\u00a0\u00bb0&Prime; text_font_size_tablet=\u00a0\u00bb\u00a0\u00bb text_font_size_phone=\u00a0\u00bb14px\u00a0\u00bb text_font_size_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb header_4_font_size_tablet=\u00a0\u00bb\u00a0\u00bb header_4_font_size_phone=\u00a0\u00bb18px\u00a0\u00bb header_4_font_size_last_edited=\u00a0\u00bbon|phone\u00a0\u00bb global_colors_info=\u00a0\u00bb{}\u00a0\u00bb sticky_enabled=\u00a0\u00bb0&Prime;]<\/p>\n<h4><strong>juillet 2025<\/strong><\/h4>\n<h4><strong>Nexavar (soraf\u00e9nib): Risque de syndrome de lyse tumorale (SLT) <\/strong><\/h4>\n<p>Des cas de SLT, certains ayant \u00e9t\u00e9 mortels, ont \u00e9t\u00e9 signal\u00e9s dans le cadre de la pharmacovigilance chez des patients trait\u00e9s par le soraf\u00e9nib.<\/p>\n<p>Les facteurs de risque de SLT sont les suivants : fardeau tumoral \u00e9lev\u00e9, insuffisance r\u00e9nale chronique pr\u00e9existante, oligurie, d\u00e9shydratation, hypotension et urine acide.<\/p>\n<p>Les patients doivent \u00eatre suivis de pr\u00e8s et trait\u00e9s rapidement si le tableau clinique le justifie. Des mesures prophylactiques seront envisag\u00e9es si cela est indiqu\u00e9 sur le plan clinique.<\/p>\n<p><strong>Plus de renseignements: <\/strong><\/p>\n<p><span><a href=\"https:\/\/www.canada.ca\/fr\/sante-canada\/services\/medicaments-produits-sante\/medeffet-canada\/infovigilance-produits-sante.html\" target=\"_blank\"><strong>InfoVigilance sur les produits de sant\u00e9<\/strong><\/a><\/span>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"<p>juillet 2025 Nexavar (soraf\u00e9nib): Risque de syndrome de lyse tumorale (SLT) Des cas de SLT, certains ayant \u00e9t\u00e9 mortels, ont \u00e9t\u00e9 signal\u00e9s dans le cadre de la pharmacovigilance chez des patients trait\u00e9s par le soraf\u00e9nib. Les facteurs de risque de SLT sont les suivants : fardeau tumoral \u00e9lev\u00e9, insuffisance r\u00e9nale chronique pr\u00e9existante, oligurie, d\u00e9shydratation, hypotension [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"class_list":["post-4417","page","type-page","status-publish","hentry"],"publishpress_future_action":{"enabled":false,"date":"2026-08-22 18:39:32","action":"change-status","newStatus":"draft","terms":[],"taxonomy":"translation_priority","extraData":[]},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/csem.ubmepsilon.com\/fr\/wp-json\/wp\/v2\/pages\/4417","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/csem.ubmepsilon.com\/fr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/csem.ubmepsilon.com\/fr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/csem.ubmepsilon.com\/fr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/csem.ubmepsilon.com\/fr\/wp-json\/wp\/v2\/comments?post=4417"}],"version-history":[{"count":4,"href":"https:\/\/csem.ubmepsilon.com\/fr\/wp-json\/wp\/v2\/pages\/4417\/revisions"}],"predecessor-version":[{"id":4421,"href":"https:\/\/csem.ubmepsilon.com\/fr\/wp-json\/wp\/v2\/pages\/4417\/revisions\/4421"}],"wp:attachment":[{"href":"https:\/\/csem.ubmepsilon.com\/fr\/wp-json\/wp\/v2\/media?parent=4417"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}